You can modify in a few seconds and advanced settings parameter for hundreds of hosts in a cluster. We will achieve this using PowerCLI.
First, we need to set a variable for cluster name. And then we issue the command (here, we want to set VMFS3.UseATSForHBOnVMFS5 to false (value 0):
$clusterName = 'My VMware Cluster'
Get-Cluster -Name $clusterName | Get-VMHost | Get-AdvancedSetting -Name VMFS3.UseATSForHBOnVMFS5 | Set-AdvancedSetting -Value 0 -Confirm:$false